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The Microbial Fermentation Technology Market size was estimated at USD 32,791.08 million in 2023 and is expected to reach USD 54,931.24 million by 2032 with a growing CAGR of 5.9% during the forecast period of 2024-2032.
Microbial fermentation happens when microorganisms like fungus create secondary metabolites. When conditions are favorable, these microorganisms may convert cheap carbon and nitrogen sources into critical intermediates or APIs. Microorganisms are used to make products that are crucial to various sectors and applications, such as biotechnology and the medical industry. Microorganisms used include bacteria and fungus.
DRIVERS
Growing research and development
Microbial fermentation technology has numerous clinical, food, and pharmaceutical applications, including the production of antibiotics, vaccines, and fermented foods. Overall, research in all of these areas is accelerating, particularly in the aftermath of the epidemic. There was an unexpected increase in the demand for novel research in the development of post-covid vaccinations and medications. In addition, the growing number of infections, chronic disorders, and rare diseases necessitates the development of novel medications and therapies. Overall, increased clinical trials, synthesis of tiny biomolecules, and biologics all demonstrate growth in research and development, necessitating the expansion of the microbial fermentation technology market.
RESTRAIN
High cost of research and development
The majority of the experimentation, raw materials, equipment, and technology utilized in pharmaceutical and biopharmaceutical research are often expensive. The high cost of these biological techniques, particularly fermentation, is influenced by economic, political, and social factors. Most of the time, microbial fermentation technology is still quite traditional. Because of the potential cost rise, many pharmaceutical companies outsource these activities to CROs and CDMOs. As a result, the high cost of microbial fermentation technology in the creation and research of innovative therapies could be a substantial restrain to the market growth.
OPPORTUNITY
Rise in consumption of fermented food
Fermented foods are becoming increasingly popular as a result of the improved health benefits it provides. Moreover, the rise of the fermented food business has been fueled by the consumption of fermented beverages, particularly beer and wine. Fermented dairy products, probiotics, and traditional fermented foods have also grown in popularity. In the food sector, microbial fermentation technology has numerous applications. As a result, the increased popularity of fermented foods will provide a significant growth potential for the microbial fermentation market.
CHALLENGES
Customer acceptance of microbial fermented based products
The ongoin Russia-Ukraine war has taken a toll on the country's pharmaceutical industry, with commerce down by at least 50% as many manufacturers who ship medications to Russia allege they have yet to be paid. Furthermore, the production cycle has been hampered because output will be hampered if manufacturers do not receive their payments on time. According to the current scenario, no feasible alternative appears to exist until the disagreement is settled. India's pharmaceutical exports to Russia account for 2.4% of overall pharmaceutical exports, while exports to Ukraine account for 0.74%. Dr Reddy's Laboratories, India's fourth-largest pharmaceutical company by market value, distributes numerous pharmaceutical products to Russia and is a key distributor of Russia's Sputnik covid-19 vaccine in India.
IMPACT OF ONGOING RECESSION
Microbial fermentation is widely promoted in the food industry, particularly in industries that directly benefit human life. Fermented foods that improve gut health and immunity are more popular than ever. There is little proof that a healthy gut improves resistance to infections and boosts survival chances, even in people who have been exposed to COVID-19. Bioforward solutions are most likely altered as a result of current events. Medical biotechnology, stem cell research, clinical trials, biofuels, molecular biology, and other life sciences disciplines are examples of emerging frontiers in medicine. For remedies to this epidemic, it appears that the world is relying more on entrepreneurs and firms in the biotech industry than on other exact sciences. Certainly, there is an increase in the development of patent items and biologic medications.
By Application
Probiotics Supplements
Monoclonal Antibodies
Vaccines
Enzymes
Small Molecules
Others
In 2022, Antibiotics segment is expected to held the highest market share of 32.3% during the forecast period due to the rising demand for antibiotics around the world, the increased focus on microbial metabolite research, and the introduction of new antibiotics into the market. Microbial fermentation is critical in the creation of antibiotics. For example, several studies, have found that 70-80% of all identified antibiotics are produced by a single type of bacteria.
By End User
Bio-Pharmaceutical Companies
CMOs & CDMOs
Academic & Research Institutes
In 2022, CMOs & CDMOs segment is expected to dominate the market growth of 42.3% during the forecast period. CMOs and CDMOs are rapidly becoming the preferred alternative for biotherapeutics producers because most bioprocess innovation is accomplished by smaller enterprises with limited capacity, a lack of educated specialists, and resources for product commercialization. Another element projected to boost this segment's growth is the constantly expanding clinical pipeline of biologics.
Asia Pacific held a significant market share of around 38.2% in 2022 owing to Asian countries recognition as a biopharmaceutical outsourcing hub. Asian enterprises, both domestic and multinational, are expected to construct around half of all new bioprocessing facilities worldwide. Several bioprocessing plants, for example, are scheduled to be built in China to suit domestic demand. The combination of the aforementioned factors would increase the region's demand for microbial fermentation technology.
North America is witness to expand fastest CAGR rate of 16.8% during the forecast period due to the increasing involvement of corporations in biologics research and product development, as well as the existence of a large number of contract development organizations in the region. Another important component in defining the North American market is a strong regulatory structure. The US FDA is still working to strengthen criteria for biopharmaceutical product promotion, development, approval, and legal practice.
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REGIONAL COVERAGE
North America
US
Canada
Mexico
Europe
Eastern Europe
Poland
Romania
Hungary
Turkey
Rest of Eastern Europe
Western Europe
Germany
France
UK
Italy
Spain
Netherlands
Switzerland
Austria
Rest of Western Europe
Asia Pacific
China
India
Japan
South Korea
Vietnam
Singapore
Australia
Rest of Asia Pacific
Middle East & Africa
Middle East
UAE
Egypt
Saudi Arabia
Qatar
Rest of Middle East
Africa
Nigeria
South Africa
Rest of Africa
Latin America
Brazil
Argentina
Colombia
Rest of Latin America
The major players are Biocon Ltd., BioVectra Inc., BioZyme, Danone UK, F. Hoffmann-La Roche AG, Koninklijke DSM NV, Lonza, Novozymes A/S, TerraVia Holdings, Inc., BIOZEEN, WuXi Biologics and Others.
BioZyme, In January 2023, BioZyme announced the release of AO-Biotics. To generate the new fermentation products, Aspergillus oryzae (AO), a strain recognized for its great resilience, is used in the company's fermentation process. Amaferm is the industry's first new product.
WuXi Biologics, in July 2022, WuXi Biologics, a leading CDMO, announced the inauguration of a new facility in China's Hangzhou province. The unit will assist in the production of microbiological goods in accordance with current good manufacturing practices (cGMP). The structure is an expansion of the company's Integrated Innovation Centre.
Lonza, in November 2021, Lonza invested over USD 1 billion to develop its microbial manufacturing capacity in Visp, Switzerland. With this investment, a 50-liter fermenter and other equipment were constructed at the location to improve development services for Lonza's microbial-derived proteins.
| Report Attributes | Details |
| Market Size in 2023 | US$ 32,791.08 Million |
| Market Size by 2032 | US$ 54,931.24 Million |
| CAGR | CAGR of 5.9% From 2024 to 2032 |
| Base Year | 2023 |
| Forecast Period | 2024-2032 |
| Historical Data | 2020-2022 |
| Report Scope & Coverage | Market Size, Segments Analysis, Competitive Landscape, Regional Analysis, DROC & SWOT Analysis, Forecast Outlook |
| Key Segments | • By Application (Antibiotics, Probiotics Supplements, Monoclonal Antibodies, Recombinant Proteins, Biosimilars, Vaccines, Enzymes, Small Molecules, Others) • By End Users (Bio-Pharmaceutical Companies, Contract Research Organizations (CROs), CMOs & CDMOs, Academic & Research Institutes) |
| Regional Analysis/Coverage | North America (US, Canada, Mexico), Europe (Eastern Europe [Poland, Romania, Hungary, Turkey, Rest of Eastern Europe] Western Europe] Germany, France, UK, Italy, Spain, Netherlands, Switzerland, Austria, Rest of Western Europe]), Asia Pacific (China, India, Japan, South Korea, Vietnam, Singapore, Australia, Rest of Asia Pacific), Middle East & Africa (Middle East [UAE, Egypt, Saudi Arabia, Qatar, Rest of Middle East], Africa [Nigeria, South Africa, Rest of Africa], Latin America (Brazil, Argentina, Colombia Rest of Latin America) |
| Company Profiles | Biocon Ltd., BioVectra Inc., BioZyme, Danone UK, F. Hoffmann-La Roche AG, Koninklijke DSM NV, Lonza, Novozymes A/S, TerraVia Holdings, Inc., BIOZEEN, WuXi Biologics |
| Key Drivers | • Growing research and development |
| Market Challenges | • Customer acceptance of microbial fermented based products |
Ans: USD 54,931.24 million is expected to grow by 2032.
Ans: Microbial Fermentation Technology Market is anticipated to expand by 5.9% from 2024 to 2032.
Ans: Microbial Fermentation Technology Market size was valued at USD 32,791.08 million in 2023.
Ans: Asia Pacific is dominating the market.
Ans: Increasing research and development and development of innovative therapies.
TABLE OF CONTENTS
1. Introduction
1.1 Market Definition
1.2 Scope
1.3 Research Assumptions
2. Research Methodology
3. Market Dynamics
3.1 Drivers
3.2 Restraints
3.3 Opportunities
3.4 Challenges
4. Impact Analysis
4.1 Impact of the Russia-Ukraine War
4.2 Impact of Ongoing Recession
4.2.1 Introduction
4.2.2 Impact on major economies
4.2.2.1 US
4.2.2.2 Canada
4.2.2.3 Germany
4.2.2.4 France
4.2.2.5 United Kingdom
4.2.2.6 China
4.2.2.7 Japan
4.2.2.8 South Korea
4.2.2.9 Rest of the World
5. Value Chain Analysis
6. Porter’s 5 forces model
7. PEST Analysis
8. Microbial Fermentation Technology Market Segmentation, By Application
8.1.1 Antibiotics
8.1.2 Probiotics Supplements
8.1.3 Monoclonal Antibodies
8.1.4 Recombinant Proteins
8.1.5 Biosimilars
8.1.6 Vaccines
8.1.7 Enzymes
8.1.8 Small Molecules
8.1.9 Others
9. Microbial Fermentation Technology Market Segmentation, By End Users
9.1.1 Bio-Pharmaceutical Companies
9.1.2 Contract Research Organizations (CROs)
9.1.3 CMOs & CDMOs
9.1.4 Academic & Research Institutes
10. Regional Analysis
10.1 Introduction
10.2 North America
10.2.1 North America Microbial Fermentation Technology Market by Country
10.2.2 North America Microbial Fermentation Technology Market by Application
10.2.3 North America Microbial Fermentation Technology Market by End Users
10.2.4 USA
10.2.4.1 USA Microbial Fermentation Technology Market by Application
10.2.4.2 USA Microbial Fermentation Technology Market by End Users
10.2.5 Canada
10.2.5.1 Canada Microbial Fermentation Technology Market by Application
10.2.5.2 Canada Microbial Fermentation Technology Market by End Users
10.2.6 Mexico
10.2.6.1 Mexico Microbial Fermentation Technology Market by Application
10.2.6.2 Mexico Microbial Fermentation Technology Market by End Users
10.3 Europe
10.3.1 Eastern Europe
10.3.1.1 Eastern Europe Microbial Fermentation Technology Market by Country
10.3.1.2 Eastern Europe Microbial Fermentation Technology Market by Application
10.3.1.3 Eastern Europe Microbial Fermentation Technology Market by End Users
10.3.1.4 Poland
10.3.1.4.1 Poland Microbial Fermentation Technology Market by Application
10.3.1.4.2 Poland Microbial Fermentation Technology Market by End Users
10.3.1.5 Romania
10.3.1.5.1 Romania Microbial Fermentation Technology Market by Application
10.3.1.5.2 Romania Microbial Fermentation Technology Market by End Users
10.3.1.6 Hungary
10.3.1.6.1 Hungary Microbial Fermentation Technology Market by Application
10.3.1.6.2 Hungary Microbial Fermentation Technology Market by End Users
10.3.1.7 Turkey
10.3.1.7.1 Turkey Microbial Fermentation Technology Market by Application
10.3.1.7.2 Turkey Microbial Fermentation Technology Market by End Users
10.3.1.8 Rest of Eastern Europe
10.3.1.8.1 Rest of Eastern Europe Microbial Fermentation Technology Market by Application
10.3.1.8.2 Rest of Eastern Europe Microbial Fermentation Technology Market by End Users
10.3.2 Western Europe
10.3.2.1 Western Europe Microbial Fermentation Technology Market by Country
10.3.2.2 Western Europe Microbial Fermentation Technology Market by Application
10.3.2.3 Western Europe Microbial Fermentation Technology Market by End Users
10.3.2.4 Germany
10.3.2.4.1 Germany Microbial Fermentation Technology Market by Application
10.3.2.4.2 Germany Microbial Fermentation Technology Market by End Users
10.3.2.5 France
10.3.2.5.1 France Microbial Fermentation Technology Market by Application
10.3.2.5.2 France Microbial Fermentation Technology Market by End Users
10.3.2.6 UK
10.3.2.6.1 UK Microbial Fermentation Technology Market by Application
10.3.2.6.2 UK Microbial Fermentation Technology Market by End Users
10.3.2.7 Italy
10.3.2.7.1 Italy Microbial Fermentation Technology Market by Application
10.3.2.7.2 Italy Microbial Fermentation Technology Market by End Users
10.3.2.8 Spain
10.3.2.8.1 Spain Microbial Fermentation Technology Market by Application
10.3.2.8.2 Spain Microbial Fermentation Technology Market by End Users
10.3.2.9 Netherlands
10.3.2.9.1 Netherlands Microbial Fermentation Technology Market by Application
10.3.2.9.2 Netherlands Microbial Fermentation Technology Market by End Users
10.3.2.10 Switzerland
10.3.2.10.1 Switzerland Microbial Fermentation Technology Market by Application
10.3.2.10.2 Switzerland Microbial Fermentation Technology Market by End Users
10.3.2.11 Austria
10.3.2.11.1 Austria Microbial Fermentation Technology Market by Application
10.3.2.11.2 Austria Microbial Fermentation Technology Market by End Users
10.3.2.12 Rest of Western Europe
10.3.2.12.1 Rest of Western Europe Microbial Fermentation Technology Market by Application
10.3.2.12.2 Rest of Western Europe Microbial Fermentation Technology Market by End Users
10.4 Asia-Pacific
10.4.1 Asia Pacific Microbial Fermentation Technology Market by Country
10.4.2 Asia Pacific Microbial Fermentation Technology Market by Application
10.4.3 Asia Pacific Microbial Fermentation Technology Market by End Users
10.4.4 China
10.4.4.1 China Microbial Fermentation Technology Market by Application
10.4.4.2 China Microbial Fermentation Technology Market by End Users
10.4.5 India
10.4.5.1 India Microbial Fermentation Technology Market by Application
10.4.5.2 India Microbial Fermentation Technology Market by End Users
10.4.6 Japan
10.4.6.1 Japan Microbial Fermentation Technology Market by Application
10.4.6.2 Japan Microbial Fermentation Technology Market by End Users
10.4.7 South Korea
10.4.7.1 South Korea Microbial Fermentation Technology Market by Application
10.4.7.2 South Korea Microbial Fermentation Technology Market by End Users
10.4.8 Vietnam
10.4.8.1 Vietnam Microbial Fermentation Technology Market by Application
10.4.8.2 Vietnam Microbial Fermentation Technology Market by End Users
10.4.9 Singapore
10.4.9.1 Singapore Microbial Fermentation Technology Market by Application
10.4.9.2 Singapore Microbial Fermentation Technology Market by End Users
10.4.10 Australia
10.4.10.1 Australia Microbial Fermentation Technology Market by Application
10.4.10.2 Australia Microbial Fermentation Technology Market by End Users
10.4.11 Rest of Asia-Pacific
10.4.11.1 Rest of Asia-Pacific Microbial Fermentation Technology Market by Application
10.4.11.2 Rest of Asia-Pacific Microbial Fermentation Technology Market by End Users
10.5 Middle East & Africa
10.5.1 Middle East
10.5.1.1 Middle East Microbial Fermentation Technology Market by Country
10.5.1.2 Middle East Microbial Fermentation Technology Market by Application
10.5.1.3 Middle East Microbial Fermentation Technology Market by End Users
10.5.1.4 UAE
10.5.1.4.1 UAE Microbial Fermentation Technology Market by Application
10.5.1.4.2 UAE Microbial Fermentation Technology Market by End Users
10.5.1.5 Egypt
10.5.1.5.1 Egypt Microbial Fermentation Technology Market by Application
10.5.1.5.2 Egypt Microbial Fermentation Technology Market by End Users
10.5.1.6 Saudi Arabia
10.5.1.6.1 Saudi Arabia Microbial Fermentation Technology Market by Application
10.5.1.6.2 Saudi Arabia Microbial Fermentation Technology Market by End Users
10.5.1.7 Qatar
10.5.1.7.1 Qatar Microbial Fermentation Technology Market by Application
10.5.1.7.2 Qatar Microbial Fermentation Technology Market by End Users
10.5.1.8 Rest of Middle East
10.5.1.8.1 Rest of Middle East Microbial Fermentation Technology Market by Application
10.5.1.8.2 Rest of Middle East Microbial Fermentation Technology Market by End Users
10.5.2 Africa
10.5.2.1 Africa Microbial Fermentation Technology Market by Country
10.5.2.2 Africa Microbial Fermentation Technology Market by Application
10.5.2.3 Africa Microbial Fermentation Technology Market by End Users
10.5.2.4 Nigeria
10.5.2.4.1 Nigeria Microbial Fermentation Technology Market by Application
10.5.2.4.2 Nigeria Microbial Fermentation Technology Market by End Users
10.5.2.5 South Africa
10.5.2.5.1 South Africa Microbial Fermentation Technology Market by Application
10.5.2.5.2 South Africa Microbial Fermentation Technology Market by End Users
10.5.2.6 Rest of Africa
10.5.2.6.1 Rest of Africa Microbial Fermentation Technology Market by Application
10.5.2.6.2 Rest of Africa Microbial Fermentation Technology Market by End Users
10.6 Latin America
10.6.1 Latin America Microbial Fermentation Technology Market by Country
10.6.2 Latin America Microbial Fermentation Technology Market by Application
10.6.3 Latin America Microbial Fermentation Technology Market by End Users
10.6.4 Brazil
10.6.4.1 Brazil Microbial Fermentation Technology Market by Application
10.6.4.2 Brazil Microbial Fermentation Technology Market by End Users
10.6.5 Argentina
10.6.5.1 Argentina Microbial Fermentation Technology Market by Application
10.6.5.2 Argentina Microbial Fermentation Technology Market by End Users
10.6.6 Colombia
10.6.6.1 Colombia Microbial Fermentation Technology Market by Application
10.6.6.2 Colombia Microbial Fermentation Technology Market by End Users
10.6.7 Rest of Latin America
10.6.7.1 Rest of Latin America Microbial Fermentation Technology Market by Application
10.6.7.2 Rest of Latin America Microbial Fermentation Technology Market by End Users
11. Company Profile
11.1 Biocon Ltd.
11.1.1 Company Overview
11.1.2 Financials
11.1.3 Application/Applications Offered
11.1.4 SWOT Analysis
11.1.5 The SNS View
11.2 BioVectra Inc.
11.2.1 Company Overview
11.2.2 Financials
11.2.3 Application/Applications Offered
11.2.4 SWOT Analysis
11.2.5 The SNS View
11.3 BioZyme
11.3.1 Company Overview
11.3.2 Financials
11.3.3 Application/Applications Offered
11.3.4 SWOT Analysis
11.3.5 The SNS View
11.4 Danone UK
11.4.1 Company Overview
11.4.2 Financials
11.4.3 Application/Applications Offered
11.4.4 SWOT Analysis
11.4.5 The SNS View
11.5 F. Hoffmann-La Roche AG
11.5.1 Company Overview
11.5.2 Financials
11.5.3 Application/Applications Offered
11.5.4 SWOT Analysis
11.5.5 The SNS View
11.6 Koninklijke DSM NV
11.6.1 Company Overview
11.6.2 Financials
11.6.3 Application/Applications Offered
11.6.4 SWOT Analysis
11.6.5 The SNS View
11.7 Lonza
11.7.1 Company Overview
11.7.2 Financials
11.7.3 Application/Applications Offered
11.7.4 SWOT Analysis
11.7.5 The SNS View
11.8 Novozymes A/S
11.8.1 Company Overview
11.8.2 Financials
11.8.3 Application/Applications Offered
11.8.4 SWOT Analysis
11.8.5 The SNS View
11.9 TerraVia Holdings, Inc.
11.9.1 Company Overview
11.9.2 Financials
11.9.3 Application/ Applications Offered
11.9.4 SWOT Analysis
11.9.5 The SNS View
11.10 BIOZEEN
11.10.1 Company Overview
11.10.2 Financials
11.10.3 Application/Applications Offered
11.10.4 SWOT Analysis
11.10.5 The SNS View
11.11 WuXi Biologics
11.11.1 Company Overview
11.11.2 Financials
11.11.3 Application/Applications Offered
11.11.4 SWOT Analysis
11.11.5 The SNS View
11.12 Others
12. Competitive Landscape
12.1 Competitive Bench marking
12.2 Market Share Analysis
12.3 Recent Developments
12.3.1 Industry News
12.3.2 Company News
12.3.3 Mergers & Acquisitions
13. USE Cases and Best Practices
14. Conclusion
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